Maruo K, Endo Y, Ito T, Takakura A, Hioki K, Iwai H
Jikken Dobutsu. 1982 Jan;31(1):47-50. doi: 10.1538/expanim1978.31.1_47.
Mouse hepatitis virus (MHV) infection occurred in athymic (nude) mice transplanted with human malignant tumors and 28 out of 38 tumor lines were contaminated with MHV. These 28 tumor lines were passaged in pathogen-free nude mice and 15 of these tumor lines (53.6%) became MHV-free. The MHV infection was eliminated in more than half of the tumor lines by passaging.
在移植了人类恶性肿瘤的无胸腺(裸)小鼠中发生了小鼠肝炎病毒(MHV)感染,38个肿瘤系中有28个被MHV污染。将这28个肿瘤系在无病原体的裸小鼠中传代,其中15个肿瘤系(53.6%)不再含有MHV。通过传代,超过一半的肿瘤系中的MHV感染被消除。