Yen C K, Yano Y, Budinger T F, Friedland R P, Derenzo S E, Huesman R H, O'Brien H A
J Nucl Med. 1982 Jun;23(6):532-7.
Positron emission tomography of the brain with 75-sec rubidium-82 obtained from a portable generator (25-day Sr-82 leads to Rb-82) was used to evaluate the integrity of the blood-brain barrier (BBB) in patients with brain tumors. Rubidium is normally excluded from the central nervous system by the intact BBB, but when the BBB is disrupted by a tumor. Rb enters and pools in the extravascular spaces of the central nervous system. Since Rb is also rapidly cleared from the blood, a high tissue-to-blood ratio of the Rb-82 tracer is achieved in regions of BBB disruption after intravenous injection. With dynamic positron emission tomographic imaging, the extravasation of the Rb tracer can be evaluated independent of the intravascular Rb concentration, and very small changes in the BBB permeability can be detected. The results of our studies in eight patients show that this technique is a promising method for evaluation of the BBB integrity in brain-tumor patients.U
利用从便携式发生器（25天的锶 - 82产生铷 - 82）获得的75秒82铷进行脑部正电子发射断层扫描，以评估脑肿瘤患者血脑屏障（BBB）的完整性。完整的血脑屏障通常会将铷排除在中枢神经系统之外，但当血脑屏障被肿瘤破坏时，铷会进入并积聚在中枢神经系统的血管外间隙中。由于铷也能迅速从血液中清除，静脉注射后，在血脑屏障破坏区域可实现82铷示踪剂的高组织与血液比值。通过动态正电子发射断层成像，可以独立于血管内铷浓度评估铷示踪剂的外渗情况，并且能够检测到血脑屏障通透性的非常小的变化。我们对八名患者的研究结果表明，该技术是评估脑肿瘤患者血脑屏障完整性的一种有前景的方法。
