Tsukiyama T, Hara T, Iio M, Kido G, Tsubokawa T
Eur J Nucl Med. 1986;12(5-6):244-8. doi: 10.1007/BF00251978.
Regional cerebral turnover of 11C following intravenous injection of 11C-1-pyruvate was investigated in 12 patients with brain tumors. The positron emission tomography (PET) image taken at 10-15 min after the injection always demonstrated a high concentration of 11C in tumor, and thus visualized precise tumor contours. This phenomenon was not influenced qualitatively by the variation of blood flow in the tumor. Brain edema associated with the tumor was not visualized. We conclude that the localization of brain tumors would be well determined by the PET scan, using 11C-1-pyruvate.
对12例脑肿瘤患者静脉注射11C-1-丙酮酸后，研究了11C在脑内的区域代谢情况。注射后10 - 15分钟拍摄的正电子发射断层扫描（PET）图像总是显示肿瘤内11C浓度很高，从而清晰显示出精确的肿瘤轮廓。这种现象在性质上不受肿瘤内血流变化的影响。与肿瘤相关的脑水肿未显示出来。我们得出结论，使用11C-1-丙酮酸进行PET扫描可以很好地确定脑肿瘤的位置。
