Hahn P, Smale F A
J Nutr. 1982 May;112(5):986-9. doi: 10.1093/jn/112.5.986.
Phosphoenolpyruvate carboxykinase activity was found to be high in the mucosa of the small intestine of suckling rats. Activity was higher proximally than distally and decreased to very low values at weaning. After weaning, feeding a high fat diet or starvation did not result in elevation of the low intestinal activity in rats. However, in mice, who also showed high activity in the suckling period, starvation, but not diet, did cause a rise. Since fructose-diphosphatase was also found in the intestinal mucosa of suckling rats, it is suggested that gluconeogenesis may occur in this tissue in the neonatal period.
在哺乳大鼠小肠黏膜中发现磷酸烯醇式丙酮酸羧激酶活性很高。近端活性高于远端，断奶时活性降至非常低的值。断奶后，给大鼠喂食高脂肪饮食或使其饥饿并不会导致肠道低活性升高。然而，在哺乳期也表现出高活性的小鼠中，饥饿而非饮食确实会导致活性升高。由于在哺乳大鼠的小肠黏膜中也发现了果糖二磷酸酶，因此有人提出在新生儿期该组织中可能发生糖异生作用。
