人体服用膳食纤维（瓜尔豆胶）期间的血浆地高辛浓度。
Plasma digoxin concentrations during administration of dietary fibre (guar gum) in man.
作者信息
Lembcke B, Häsler K, Kramer P, Caspary W F, Creutzfeldt W
出版信息
Z Gastroenterol. 1982 Mar;20(3):164-7.
PMID:6282000
Abstract
The effect of guar gum on digoxin absorption was investigated in eleven healthy volunteers. The drug was administered in the morning during two five-day-periods, together with a liquid mixed test meal (+/- 18 g guar). By measuring plasma digoxin concentrations no differences were registered between the control and guar gum period. It is concluded that long-term administration of guar gum will not interfere with adequate digitalization (digoxin bioavailability).
摘要
在11名健康志愿者中研究了瓜尔胶对地高辛吸收的影响。在两个为期五天的时间段内，于早晨将该药物与一份液体混合试验餐（±18克瓜尔胶）一起给药。通过测量血浆地高辛浓度，未发现对照组和瓜尔胶组之间存在差异。得出的结论是，长期服用瓜尔胶不会干扰地高辛的充分洋地黄化（地高辛生物利用度）。
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