羟羧氧酰胺菌素单独及与庆大霉素联合对铜绿假单胞菌的杀菌及协同活性。
Bactericidal and synergistic activity of moxalactam alone and in combination with gentamicin against Pseudomonas aeruginosa.
作者信息
Yu P K, Edson R S, Washington J A, Hermans P E
出版信息
Antimicrob Agents Chemother. 1983 Jan;23(1):179-81. doi: 10.1128/AAC.23.1.179.
Abstract
The bactericidal activity of moxalactam, alone and in combination with gentamicin, was studied with macrobroth two-dimensional checkerboard and killing curve techniques against gentamicin-resistant and -susceptible strains of Pseudomonas aeruginosa. Moxalactam was bactericidal at concentrations equal to or at least two to four times its inhibitory concentrations. Synergy at clinically applicable concentrations of moxalactam and gentamicin occurred with 6 of 14 gentamicin-resistant strains and 4 of 4 gentamicin-susceptible strains by the checkerboard technique and with 7 of 14 gentamicin-resistant strains by the killing curve technique. Synergy between moxalactam and gentamicin against gentamicin-resistant strains of P. aeruginosa is unpredictable and strain- and method-dependent.
摘要
采用常量肉汤二维棋盘法和杀菌曲线技术，研究了氨曲南单独使用及与庆大霉素联合使用时，对庆大霉素耐药和敏感的铜绿假单胞菌菌株的杀菌活性。氨曲南在等于或至少为其抑菌浓度两到四倍的浓度下具有杀菌作用。通过棋盘法，在氨曲南和庆大霉素的临床适用浓度下，14株庆大霉素耐药菌株中有6株、4株庆大霉素敏感菌株中有4株出现协同作用；通过杀菌曲线技术，14株庆大霉素耐药菌株中有7株出现协同作用。氨曲南与庆大霉素对铜绿假单胞菌庆大霉素耐药菌株的协同作用是不可预测的，且取决于菌株和方法。
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