单药及联合使用时，羟羧氧酰胺菌素和美西林对多重耐药肠杆菌科细菌及假单胞菌属细菌的体外活性。
In vitro activity of moxalactam and mecillinam, singly and in combination, against multi-drug-resistant Enterobacteriaceae and Pseudomonas species.
作者信息
Fass R J
出版信息
Antimicrob Agents Chemother. 1982 Jan;21(1):188-91. doi: 10.1128/AAC.21.1.188.
Abstract
The in vitro interaction of moxalactam and mecillinam against multi-drug-resistant gram-negative enteric bacilli was studied by checkerboard microdilution susceptibility tests and by killing curve kinetics. Against Enterobacteriaceae, the combination was unpredictable; the frequencies of synergy, indifference, and antagonism were 11, 76, and 13%, respectively. Against Pseudomonas sp., the two drugs were consistently indifferent. Overall, the combination of moxalactam and mecillinam was no more active than moxalactam alone.
摘要
通过棋盘微量稀释药敏试验和杀菌曲线动力学研究了莫西拉坦和美西林对多重耐药革兰氏阴性肠道杆菌的体外相互作用。对于肠杆菌科细菌，联合用药的结果不可预测；协同、无差异和拮抗的频率分别为11%、76%和13%。对于假单胞菌属，这两种药物始终无差异。总体而言，莫西拉坦和美西林联合使用并不比单独使用莫西拉坦更有效。
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