阿洛西林-头孢噻肟与阿洛西林-妥布霉素联合用药对血液及多重耐药菌分离株的体外比较活性
Comparative in vitro activities of azlocillin-cefotaxime and azlocillin-tobramycin combinations against blood and multi-drug resistant bacterial isolates.
作者信息
Fass R J
出版信息
Antimicrob Agents Chemother. 1982 Jul;22(1):167-9. doi: 10.1128/AAC.22.1.167.
Abstract
The in vitro activities of azlocillin and cefotaxime in combination and of azlocillin and tobramycin in combination against 100 blood isolates and 50 multidrug-resistant isolates were compared. With both combinations, antibacterial spectrums were complementary. Although synergy against individual strains was infrequently observed (except for azlocillin-cefotaxime against Streptococcus faecalis and azlocillin-tobramycin against Pseudomonas aeruginosa), 97% of blood isolates and 76% of multidrug-resistant isolates were susceptible to azlocillin-cefotaxime, and 94% of blood isolates and 36% of multidrug-resistant isolates were susceptible to azlocyclin-tobramycin.
摘要
比较了阿洛西林与头孢噻肟联合以及阿洛西林与妥布霉素联合对100株血液分离株和50株多重耐药分离株的体外活性。两种联合用药的抗菌谱具有互补性。虽然很少观察到对个别菌株有协同作用（除阿洛西林 - 头孢噻肟对粪肠球菌以及阿洛西林 - 妥布霉素对铜绿假单胞菌外），但97%的血液分离株和76%的多重耐药分离株对阿洛西林 - 头孢噻肟敏感，94%的血液分离株和36%的多重耐药分离株对阿洛西林 - 妥布霉素敏感。
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