Rossowski W, Blaszczyk M, Darai G, Munk K
Oncology. 1982;39(4):222-7. doi: 10.1159/000225642.
Total and superficially exposed plasma membrane components of tumorigenic herpes-simplex-virus (HSV)-transformed fibroblasts were studied. As a result of oncogenic HSV transformation, a significant decrease of polypeptides 230,000, 180,000, 56,000 and 43,000 daltons was found. These changes were accompanied by a significant increase in superficial exposition of several sialopeptides and two peptides of 30,000 and 15,000 daltons. It was suggested that these two peptides may represent virus-coded components of HSV-transformed fibroblasts. The present results indicate that the HSV-transformed tumorigenic cell clone meets all previously described criteria for oncogenically transformed cells.
对致瘤性单纯疱疹病毒（HSV）转化的成纤维细胞的全部及表面暴露的质膜成分进行了研究。由于致癌性HSV转化，发现分子量为230,000、180,000、56,000和43,000道尔顿的多肽显著减少。这些变化伴随着几种唾液酸肽以及分子量为30,000和15,000道尔顿的两种肽的表面暴露显著增加。有人提出，这两种肽可能代表HSV转化的成纤维细胞的病毒编码成分。目前的结果表明，HSV转化的致瘤细胞克隆符合先前描述的所有致癌转化细胞的标准。
