Utsumi R, Nakamoto Y, Kawamukai M, Himeno M, Komano T
J Bacteriol. 1982 Aug;151(2):807-12. doi: 10.1128/jb.151.2.807-812.1982.
Cyclic AMP (cAMP) inhibited septum formation in Escherichia coli PA3092 and induced cell filamentation at elevated temperatures. This phenomenon was first observed in E. coli PA3092 and is due to a temperature-sensitive mutation. We tentatively named this mutation fic (filamentation induced by cAMP). The fic gene was located near rpsL (formerly strA) on the E. coli K-12 map. the inhibitory effect of cAMP on cell division and filamentation in a fic mutant was not observed in a crp mutant. When cAMP was removed from the culture medium, filaments were divided into rods as the intracellular cAMP level decreased. These results suggest that the cAMP-cAMP receptor protein complex causes filamentation in the fic mutant, E. coli PA3092.
环磷酸腺苷（cAMP）抑制大肠杆菌PA3092中隔膜的形成，并在高温下诱导细胞丝状化。这种现象首次在大肠杆菌PA3092中观察到，是由一个温度敏感突变引起的。我们暂定将此突变命名为fic（由cAMP诱导的丝状化）。fic基因位于大肠杆菌K-12图谱上的rpsL（以前的strA）附近。在crp突变体中未观察到cAMP对fic突变体细胞分裂和丝状化的抑制作用。当从培养基中去除cAMP时，随着细胞内cAMP水平的降低，丝状体会分裂成杆状。这些结果表明，cAMP- cAMP受体蛋白复合物在fic突变体大肠杆菌PA3092中引起丝状化。
