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Antipain lethality to Escherichia coli: dependence upon cyclic adenosine 3',5'-monophosphate and its receptor protein.

作者信息

Swenson P A

出版信息

J Bacteriol. 1979 Aug;139(2):690-3. doi: 10.1128/jb.139.2.690-693.1979.

Abstract

Antipain kills Escherichia coli K-12 cells in an exponential manner beginning 1 h after its addition. Mutant strains, delta cya and crp, which are unable to synthesize cyclic adenosine 3',5'-monophosphate (cAMP) and the cAMP receptor protein, respectively, are not affected. Addition of cAMP (5 mM) to antipain-treated mutant strains causes killing of delta cya cells, but not crp cells. Thus the lethal effect of antipain is dependent upon cAMP and its receptor protein.

摘要

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本文引用的文献

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Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate synthetase I in tadpole liver.
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5339-43. doi: 10.1073/pnas.75.11.5339.

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