抗痛素对大肠杆菌的致死作用：依赖于环腺苷酸3',5'-单磷酸及其受体蛋白。
Antipain lethality to Escherichia coli: dependence upon cyclic adenosine 3',5'-monophosphate and its receptor protein.
作者信息
Swenson P A
出版信息
J Bacteriol. 1979 Aug;139(2):690-3. doi: 10.1128/jb.139.2.690-693.1979.
Abstract
Antipain kills Escherichia coli K-12 cells in an exponential manner beginning 1 h after its addition. Mutant strains, delta cya and crp, which are unable to synthesize cyclic adenosine 3',5'-monophosphate (cAMP) and the cAMP receptor protein, respectively, are not affected. Addition of cAMP (5 mM) to antipain-treated mutant strains causes killing of delta cya cells, but not crp cells. Thus the lethal effect of antipain is dependent upon cAMP and its receptor protein.
摘要
抗痛素在添加后1小时开始以指数方式杀死大肠杆菌K-12细胞。分别无法合成环腺苷3',5'-单磷酸（cAMP）和cAMP受体蛋白的突变菌株delta cya和crp不受影响。向经抗痛素处理的突变菌株中添加cAMP（5 mM）会导致delta cya细胞死亡，但不会导致crp细胞死亡。因此，抗痛素的致死作用取决于cAMP及其受体蛋白。
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