Schnipper L E, Crumpacker C S, Marlowe S I, Kowalsky P, Hershey B J, Levin M J
Am J Med. 1982 Jul 20;73(1A):387-92. doi: 10.1016/0002-9343(82)90129-2.
An acyclovir-resistant herpes simplex virus (HSV) has been isolated from an immunocompromised patient during treatment for severe orofacial HSV infections with acyclovir. The resistant virus is deficient in expression of the HSV thymidine kinase (TK). Emergence of acyclovir resistance during clinical use appears to parallel the in vitro observations of selection for TK-deficient, acyclovir-resistant viruses following serial passage in the presence of the drug. The clinical importance of drug-resistant HSV in unclear, and further investigations are required to determine whether it will be an impediment to successful therapy of HSV infections.
在一名免疫功能低下的患者接受阿昔洛韦治疗严重口面部单纯疱疹病毒（HSV）感染期间，分离出了一株对阿昔洛韦耐药的HSV。该耐药病毒的HSV胸苷激酶（TK）表达缺陷。临床使用过程中阿昔洛韦耐药性的出现似乎与在药物存在下连续传代后选择TK缺陷、阿昔洛韦耐药病毒的体外观察结果相似。耐药HSV的临床重要性尚不清楚，需要进一步研究以确定它是否会成为HSV感染成功治疗的障碍。
