Larder B A, Darby G
Virology. 1985 Oct 30;146(2):262-71. doi: 10.1016/0042-6822(85)90009-1.
A collection of TK+, ACV-resistant mutants of herpes simplex virus type 1 (HSV-1) has been derived using a selection system based on biochemically transformed cells. Evidence is presented suggesting that most of these mutants induce resistant DNA polymerase activities and are thus likely to express variant DNA polymerases. Preliminary data on the pathogenesis of these mutants show that most are similar to wild type virus in the majority of their characteristics, although they may be reduced in their ability to kill mice.
利用基于生化转化细胞的筛选系统，已获得了一组单纯疱疹病毒1型（HSV-1）的胸苷激酶阳性（TK+）、对阿昔洛韦耐药的突变体。有证据表明，这些突变体中的大多数诱导产生耐药性DNA聚合酶活性，因此可能表达变异的DNA聚合酶。关于这些突变体发病机制的初步数据表明，尽管它们杀死小鼠的能力可能有所降低，但大多数在其大多数特征上与野生型病毒相似。
