所选新型β-内酰胺类抗菌药物对淋病奈瑟菌的体外活性比较
Comparative in-vitro activity of selected new beta-lactam antimicrobials against Neisseria gonorrhoeae.
作者信息
Khan M Y, Siddiqui Y, Gruninger R P
出版信息
Br J Vener Dis. 1982 Aug;58(4):228-30. doi: 10.1136/sti.58.4.228.
Abstract
Four new beta-lactam antimicrobials, ceftriaxone, cefotiam, cefonicid, and mecillinam, were evaluated in vitro against 72 beta-lactamase-negative and 26 beta-lactamase-positive isolates of Neisseria gonorrhoeae. Ceftriaxone was the most active of the antimicrobials tested. It inhibited all isolates, regardless of beta-lactamase activity, at a concentration of less than or equal to 0.015 microgram/ml. Cefotiam and cefonicid were also active against both groups but not as active as ceftriaxone. Both groups of N gonorrhoeae showed a high degree of resistance against mecillinam.
摘要
对头孢曲松、头孢替安、头孢尼西和美西林这四种新型β-内酰胺类抗菌药物进行了体外评估，以检测其对72株β-内酰胺酶阴性和26株β-内酰胺酶阳性淋病奈瑟菌的抗菌活性。头孢曲松是所测试抗菌药物中活性最强的。它能抑制所有分离株，无论其β-内酰胺酶活性如何，浓度小于或等于0.015微克/毫升。头孢替安和头孢尼西对两组分离株也有活性，但不如头孢曲松。两组淋病奈瑟菌对美西林均表现出高度耐药性。
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