新型头孢菌素HR 756对淋病奈瑟菌的体外活性
In vitro activity of HR 756, a new cephalosporin, against Neisseria gonorrhoeae.
作者信息
Murray P R, Christman J L, Medoff G
出版信息
Antimicrob Agents Chemother. 1979 Mar;15(3):452-4. doi: 10.1128/AAC.15.3.452.
Abstract
The in vitro activity of HR 756 was compared with penicillin, cefamandole, cefoxitin, and tetracycline against Neisseria gonorrhoeae. A total of 192 randomly selected isolates (of which 23 had minimal inhibitory concentrations of >/=0.5 mug/ml for penicillin) and three beta-lactamase-producing isolates were tested. HR 756 was the most active antibiotic tested, with more than 90% of the isolates inhibited by 0.008 mug/ml and all inhibited by 0.25 mug/ml.
摘要
将HR 756与青霉素、头孢孟多、头孢西丁和四环素针对淋病奈瑟菌的体外活性进行了比较。总共测试了192株随机选择的分离株（其中23株对青霉素的最低抑菌浓度≥0.5μg/ml）以及3株产β-内酰胺酶的分离株。HR 756是所测试的最具活性的抗生素，超过90%的分离株被0.008μg/ml抑制，所有分离株均被0.25μg/ml抑制。
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