Oon C J, Friedman M A
Cancer Chemother Pharmacol. 1982;8(2):231-5. doi: 10.1007/BF00255489.
Primary hepatocellular cancer is a common and virulent malignancy found all over the world. New insights into this disease are being provided by evaluation of the impact of epidemiologic data (hepatitis viral exposure, race, sex, HLA typing, and environmental factors). An enhanced appreciation of the biochemical modulators of hepatocellular cancer metabolism is now also possible. The limited success of current therapies is far from satisfactory, but prospects for the future seem more varied and promising than ever before.
原发性肝细胞癌是一种在全球范围内常见且恶性程度高的肿瘤。对流行病学数据（肝炎病毒暴露、种族、性别、人类白细胞抗原分型和环境因素）影响的评估为该疾病带来了新的见解。目前，人们对肝细胞癌代谢的生化调节因子也有了更深入的认识。当前治疗方法取得的有限成功远不能令人满意，但未来的前景似乎比以往任何时候都更加多样且充满希望。
