核苷三磷酸对未感染和单纯疱疹病毒感染的HeLa细胞中核糖核苷酸还原酶的差异作用。
Differential effect of nucleoside analog triphosphates on ribonucleotide reductases from uninfected and herpes simplex virus-infected HeLa cells.
作者信息
Nakayama K, Ruth J L, Cheng Y C
出版信息
J Virol. 1982 Jul;43(1):325-7. doi: 10.1128/JVI.43.1.325-327.1982.
Abstract
Effects of the triphosphates of eight pyrimidine nucleoside analogs (5-substituted, 2'-fluoroara-, and acyclonucleosides) and acycloguanosine were examined on the ribonucleotide reductases prepared from uninfected and herpes simplex virus (types 1 and 2)-infected HeLa cells. Of the analogs tested, E-5-propenyl- and E-5-(2-bromovinyl)-dUTP were more potent inhibitors than dTTP of the enzymes from virus-infected cells, whereas only the former compound showed this effect on the uninfected HeLa enzyme.
摘要
研究了8种嘧啶核苷类似物（5-取代、2'-氟阿糖核苷和无环核苷）的三磷酸盐以及无环鸟苷对从未感染和单纯疱疹病毒（1型和2型）感染的HeLa细胞制备的核糖核苷酸还原酶的影响。在所测试的类似物中，E-5-丙烯基-dUTP和E-5-（2-溴乙烯基）-dUTP对病毒感染细胞中的酶的抑制作用比dTTP更强，而只有前一种化合物对未感染的HeLa细胞的酶有这种作用。
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