人类免疫球蛋白Cγ1基因的核苷酸序列。
The nucleotide sequence of a human immunoglobulin C gamma1 gene.
作者信息
Ellison J W, Berson B J, Hood L E
出版信息
Nucleic Acids Res. 1982 Jul 10;10(13):4071-9. doi: 10.1093/nar/10.13.4071.
Abstract
We report the nucleotide sequence of a gene encoding the constant region of a human immunoglobulin gamma 1 heavy chain (C gamma 1). A comparison of this sequence with those of the C gamma 2 and C gamma 4 genes reveals that these three human C gamma genes share considerable homology in both coding and noncoding regions. The nucleotide sequence differences indicate that these genes diverged from one another approximately 608 million years ago. An examination of hinge exons shows that these coding regions have evolved more rapidly than any other areas of the C gamma genes in terms of both base substitution and deletion/insertion events. Coding sequence diversity also is observed in areas of CH domains which border the hinge.
摘要
我们报道了编码人免疫球蛋白γ1重链恒定区（Cγ1）的基因的核苷酸序列。将该序列与Cγ2和Cγ4基因的序列进行比较，发现这三个人类Cγ基因在编码区和非编码区都具有相当高的同源性。核苷酸序列差异表明这些基因大约在6亿8千万年前彼此分化。对铰链外显子的研究表明，就碱基替换和缺失/插入事件而言，这些编码区的进化速度比Cγ基因的任何其他区域都要快。在与铰链相邻的CH结构域区域也观察到编码序列的多样性。
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