免疫球蛋白重链的结构域和铰链区由不同的DNA片段编码。

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments.

作者信息

Sakano H, Rogers J H, Hüppi K, Brack C, Traunecker A, Maki R, Wall R, Tonegawa S

出版信息

Nature. 1979 Feb 22;277(5698):627-33. doi: 10.1038/277627a0.

Abstract

A 6.8-kilobase DNA fragment containing the sequence coding for the constant region of the mouse immunoglobulin gamma1 heavy chain was cloned from total cellular DNA. Electron microscopic and nucleotide sequencing studies showed that the three protein domains and the hinge region are encoded in separate DNA segments.

摘要

从小鼠细胞总DNA中克隆出一个6.8千碱基的DNA片段，该片段含有编码小鼠免疫球蛋白γ1重链恒定区的序列。电子显微镜和核苷酸测序研究表明，三个蛋白质结构域和铰链区是由不同的DNA片段编码的。