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Rabies viruses increase in virulence when propagated in neuroblastoma cell culture.

作者信息

Clark H F

出版信息

Science. 1978 Mar 10;199(4333):1072-5. doi: 10.1126/science.628831.

DOI:10.1126/science.628831
PMID:628831
Abstract

Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.

摘要

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