以海藻糖二霉菌酸酯水悬浮液为佐剂对兔子进行抗溶组织内阿米巴疫苗接种。
Vaccination of rabbits against Entamoeba histolytica with aqueous suspensions of trehalose-dimycolate as the adjuvant.
作者信息
Sharma A, Haq A, Ahmad S, Lederer E
出版信息
Infect Immun. 1985 Jun;48(3):634-7. doi: 10.1128/iai.48.3.634-637.1985.
Abstract
Rabbits were immunized with soluble Entamoeba histolytica antigen with an aqueous suspension of trehalose-6,6'-dimycolate used as the adjuvant. Induction of protective immunity in the immunized animals was demonstrated by enhanced humoral and cell-mediated immune responses and 100% survival after challenge. Administration of soluble antigen only failed to induce a similar degree of protective immunity. Trehalose-6,6'-dimycolate alone produced only a slight increase in nonspecific resistance.
摘要
用海藻糖-6,6'-二霉菌酸的水悬浮液作为佐剂，用可溶性溶组织内阿米巴抗原对兔子进行免疫。通过增强体液免疫和细胞介导的免疫反应以及攻击后100%的存活率，证明了免疫动物中诱导出了保护性免疫。仅给予可溶性抗原未能诱导出类似程度的保护性免疫。单独使用海藻糖-6,6'-二霉菌酸仅使非特异性抵抗力略有增加。
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