Ketiladze E S, Alekseeva I L, Shakhgil'dian I V, Meĭnard D E
Vopr Virusol. 1982 May-Jun;27(3):305-8.
The study included 119 children and 138 adults suffering from viral hepatitis A. The controls consisted of 114 adult patients with hepatitis B. Examinations of the total antibody to hepatitis. A virus revealed a rise in titres from 1 : 450 in the first days of the disease to 1 : 4 400 in the convalescent period. In the acute period the antibodies were represented by immunoglobulins M which circulate in the blood up to 4-5 months of convalescence. At 3-4 weeks after the onset of the disease, synthesis of immunoglobulins G begins which are anamnestic antibodies. The importance of specific immunoglobulins M in virus elimination from the host and their role in the early diagnosis of the disease have been demonstrated.
该研究纳入了119名儿童和138名患有甲型病毒性肝炎的成人。对照组由114名乙型肝炎成年患者组成。对甲型肝炎病毒总抗体的检测显示，抗体滴度从疾病初期的1:450上升至恢复期的1:4400。在急性期，抗体以免疫球蛋白M形式存在，其在血液中循环直至恢复期的4至5个月。在疾病发作后3至4周，开始合成免疫球蛋白G，其为回忆性抗体。已证实特异性免疫球蛋白M在从宿主体内清除病毒中的重要性及其在疾病早期诊断中的作用。
