鸟分枝杆菌-胞内分枝杆菌：同性恋者和药物滥用者中播散性危及生命感染的一个病因。

Mycobacterium avium-intracellulare: a cause of disseminated life-threatening infection in homosexuals and drug abusers.

作者信息

Greene J B, Sidhu G S, Lewin S, Levine J F, Masur H, Simberkoff M S, Nicholas P, Good R C, Zolla-Pazner S B, Pollock A A, Tapper M L, Holzman R S

出版信息

Ann Intern Med. 1982 Oct;97(4):539-46. doi: 10.7326/0003-4819-97-4-539.

DOI:10.7326/0003-4819-97-4-539

PMID:6289714

Abstract

Five men developed disseminated infection with Mycobacterium avium-intracellulare. These patients all lived in the New York City area and presented with their illnesses between January 1981 and September 1981; four were homosexual and one was an intravenous drug abuser. Four patients died. All five patients had defects in the cell-mediated immune response. The infections were characterized histopathologically by poor or absent granulomatous tissue reaction. Clinical isolates of M. avium-intracellulare from all five patients agglutinated commonly used antimycobacterial drugs. The spectrum of opportunistic infections among populations of homosexuals and drug abusers should be expanded to include disseminated disease due to M. avium-intracellulare.

摘要

五名男性发生了鸟分枝杆菌-胞内分枝杆菌播散性感染。这些患者均居住在纽约市地区，于1981年1月至1981年9月期间发病；其中四名是同性恋者，一名是静脉吸毒者。四名患者死亡。所有五名患者的细胞介导免疫反应均有缺陷。感染的组织病理学特征为肉芽肿组织反应不良或缺乏。从所有五名患者中分离出的鸟分枝杆菌-胞内分枝杆菌临床菌株对常用抗分枝杆菌药物均有凝集作用。同性恋者和吸毒者群体中的机会性感染谱应扩大到包括鸟分枝杆菌-胞内分枝杆菌所致的播散性疾病。