Lemon S M, LeDuc J W, Binn L N, Escajadillo A, Ishak K G
J Med Virol. 1982;10(1):25-36. doi: 10.1002/jmv.1890100105.
The presence of antibody to hepatitis A virus (anti-HAV) in 60% of procured owl monkeys (Aotus trivirgatus) held within the United States prompted a study of recently captured A trivirgatus in Panama. Only 2 of 145 newly captured monkeys, but all of 35 A trivirgatus held within a colony for over 100 days, were found to have anti-HAV. Of 41 sero-negative, newly captured monkeys followed prospectively, 25 became infected with hepatitis A virus (HAV) as evidenced by seroconversion or demonstration of virus in the liver at death. Only one monkey that survived over 60 days within the colony was not infected. HAV was identified in the feces of most infected monkeys prior to the development of antibody and was antigenically indistinguishable from human HAV in cross-blocking radioimmunoassays. This colony-centered epizootic provides strong evidence that A trivirgatus is susceptible to HAV and should be investigated further as a potential model of human hepatitis A.
在美国圈养的60%的夜猴（Aotus trivirgatus）体内存在甲型肝炎病毒抗体（抗-HAV），这促使人们对最近在巴拿马捕获的夜猴进行研究。在145只新捕获的猴子中，只有2只检测出抗-HAV，但在一个群体中饲养超过100天的35只夜猴全部检测出抗-HAV。在对41只新捕获的血清阴性猴子进行前瞻性跟踪研究中，有25只感染了甲型肝炎病毒（HAV），这通过血清转化或死后在肝脏中检测到病毒得以证实。在群体中存活超过60天的猴子中，只有一只未被感染。在大多数感染猴子出现抗体之前，其粪便中就检测到了HAV，并且在交叉阻断放射免疫测定中，该病毒在抗原性上与人类HAV无法区分。这种以群体为中心的动物流行病提供了强有力的证据，表明夜猴对HAV易感，应作为人类甲型肝炎的潜在模型进一步研究。
