Hays E F, Margaretten N, Swanson S K
J Natl Cancer Inst. 1982 Nov;69(5):1077-82.
The spontaneous leukemia (SL) viruses are ecotropic lymphomagenic viruses isolated from AKR spontaneous lymphomas. These viruses are produced stably by continuous cell lines from spontaneous lymphomas and by a cell line derived from the bone marrow stroma of an AKR mouse neonatally inoculated with an SL virus. All cell lines cloned from the parent lymphoma cell lines consistently produce SL viruses. These viruses can be passaged in vivo and maintain their leukemogenic properties. Cloned isolates of SL viruses accelerate lymphoma in AKR mice and induce thymic lymphoma in mice of other strains. Thus their lymphomagenic properties are conclusively shown. In a study with the use of a sensitive host range assay, xenotropic and/or dual-host range viruses are consistently found in spontaneous lymphoma and cell lines derived from them. However, viruses able to replicate in mink lung cells are not expressed in SL virus-induced lymphomas or their derived cell lines.
自发性白血病（SL）病毒是从AKR自发性淋巴瘤中分离出的亲嗜性致淋巴瘤病毒。这些病毒由来自自发性淋巴瘤的连续细胞系以及源自新生时接种SL病毒的AKR小鼠骨髓基质的细胞系稳定产生。从亲代淋巴瘤细胞系克隆的所有细胞系均持续产生SL病毒。这些病毒可在体内传代并保持其致白血病特性。SL病毒的克隆分离株可加速AKR小鼠的淋巴瘤发生，并在其他品系小鼠中诱导胸腺淋巴瘤。因此，它们的致淋巴瘤特性得到了确凿证明。在一项使用敏感宿主范围测定法的研究中，在自发性淋巴瘤及其衍生的细胞系中始终发现嗜异性和/或双宿主范围病毒。然而，能够在貂肺细胞中复制的病毒在SL病毒诱导的淋巴瘤或其衍生的细胞系中不表达。
