一类与自发性淋巴瘤发生相关的新型鼠白血病病毒。
A new class of murine leukemia virus associated with development of spontaneous lymphomas.
作者信息
Hartley J W, Wolford N K, Old L J, Rowe W P
出版信息
Proc Natl Acad Sci U S A. 1977 Feb;74(2):789-92. doi: 10.1073/pnas.74.2.789.
Abstract
A new type of murine leukemia virus has been detected in thymuses of leukemic and late preleukemic AKR mice, in lymphomas developing in NIH Swiss mice carrying the AKR ectopic virus-inducing loci Akv-I or Akv-2, and in the thymus of a preleukemic C58 mouse. The viruses induce focal areas of morphologic alteration in a mink lung cell line and are tentatively referred to as "mink cell focus-inducing" (MCF) strains. They have the host range of both xenotropic and N-tropic ecotropic murine leukemia viruses, are neutralized by antisera to both ecotropic and xenotropic viruses, and are interfered with by both viruses. They may represent a particular type of genetic recombinant which emerges during the preleukemic period in high-ecotropic-virus mouse strains, and they may play a significant role in the etiology of spontaneous lymphomas.
摘要
在患白血病的和处于白血病前期的AKR小鼠的胸腺中，在携带AKR异位病毒诱导位点Akv-1或Akv-2的NIH瑞士小鼠发生的淋巴瘤中，以及在一只白血病前期C58小鼠的胸腺中，检测到了一种新型鼠白血病病毒。这些病毒在貂肺细胞系中诱导形态学改变的病灶区域，暂被称为“貂细胞集落诱导”（MCF）毒株。它们具有嗜异性和N-嗜性亲嗜性鼠白血病病毒的宿主范围，能被亲嗜性病毒和嗜异性病毒的抗血清中和，且受到这两种病毒的干扰。它们可能代表了一种在高亲嗜性病毒小鼠品系的白血病前期出现的特殊基因重组体类型，并且可能在自发性淋巴瘤的病因学中发挥重要作用。
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Acceleration of leukemogenesis in AKR mice by grafts, cell suspensions, and cell-free centrifugates of thymuses from preleukemic AKR donors.来自白血病前期AKR供体胸腺的移植组织、细胞悬液和无细胞离心液对AKR小鼠白血病发生的加速作用。
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