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小鼠组氨酸tRNA基因的分离与核苷酸序列

Isolation and nucleotide sequence of a mouse histidine tRNA gene.

作者信息

Han J H, Harding J D

出版信息

Nucleic Acids Res. 1982 Aug 25;10(16):4891-900. doi: 10.1093/nar/10.16.4891.

DOI:10.1093/nar/10.16.4891
PMID:6290993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320839/
Abstract

We have sequenced a 1307 base pair mouse genomic DNA fragment which contains a histidine tRNA gene. The sequence of the putative mouse histidine tRNA differs from the published sequence of sheep liver histidine tRNA by a single base change in the D-loop. It does not contain an unpaired 5' terminal G residue, as reported for Drosophila and sheep histidine tRNAs. The gene does not contain introns. The 3' flanking region contains a typical RNA polymerase III termination site of 6 consecutive T residues. 523 residues after the 3' end of the his tRNA coding region, the mouse DNA contains a sequence 72% homologous to part of the consensus sequence of the B1 (alu) family.

摘要

我们对一段1307个碱基对的小鼠基因组DNA片段进行了测序，该片段包含一个组氨酸tRNA基因。推测的小鼠组氨酸tRNA序列与已发表的绵羊肝脏组氨酸tRNA序列在D环处有一个单碱基变化。它不像果蝇和绵羊组氨酸tRNA那样含有未配对的5'末端G残基。该基因不含内含子。3'侧翼区域包含一个由6个连续T残基组成的典型RNA聚合酶III终止位点。在组氨酸tRNA编码区3'端之后的523个残基处，小鼠DNA包含一个与B1（alu）家族共有序列部分同源性为72%的序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4409/320839/ed1ed09bda41/nar00385-0072-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4409/320839/e609c353877c/nar00385-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4409/320839/ed1ed09bda41/nar00385-0072-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4409/320839/e609c353877c/nar00385-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4409/320839/ed1ed09bda41/nar00385-0072-b.jpg

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2
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3
Isolation and characterization of genomic mouse DNA clones containing sequences homologous to tRNAs and 5S rRNA.

本文引用的文献

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The 1980 pittsburgh conference: a special instrumentation report.
Science. 1980 Apr 11;208(4440):161-3. doi: 10.1126/science.208.4440.161.
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The nucleotide sequence of the ubiquitous repetitive DNA sequence B1 complementary to the most abundant class of mouse fold-back RNA.与最丰富的一类小鼠回折RNA互补的普遍存在的重复DNA序列B1的核苷酸序列。
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Nucleotide sequence of genes coding for tRNAPhe and tRNATyr from a repeating unit of X. laevis DNA.来自非洲爪蟾DNA重复单元的编码苯丙氨酸tRNA和酪氨酸tRNA的基因的核苷酸序列。
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Post-transcriptional nucleotide addition is responsible for the formation of the 5' terminus of histidine tRNA.转录后核苷酸添加负责组氨酸tRNA 5'末端的形成。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6475-9. doi: 10.1073/pnas.79.21.6475.
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A mammalian tRNAHis-containing antigen is recognized by the polymyositis-specific antibody anti-Jo-1.一种含哺乳动物组氨酸转运RNA的抗原可被多发性肌炎特异性抗体抗Jo-1识别。
Nucleic Acids Res. 1983 Feb 11;11(3):853-70. doi: 10.1093/nar/11.3.853.
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Processing of mammalian tRNA transcripts in vitro: different pre-tRNAs are processed along alternative pathways that contain a common rate-limiting step.体外加工哺乳动物tRNA转录本：不同的前体tRNA沿着包含共同限速步骤的替代途径进行加工。
Nucleic Acids Res. 1986 Jun 25;14(12):4849-64. doi: 10.1093/nar/14.12.4849.
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Mol Cell Biol. 1986 Jan;6(1):105-15. doi: 10.1128/mcb.6.1.105-115.1986.
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Proc Natl Acad Sci U S A. 1985 Mar;82(5):1341-5. doi: 10.1073/pnas.82.5.1341.
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