Sieber B, Frischknecht H R, Waser P G
Psychopharmacology (Berl). 1980;70(2):149-54. doi: 10.1007/BF00435306.
The acute and subchronic effects of hashish extract (20 mg delta 9-THC/kg) on the behavior of male mice encountering a control partner was studied by ethological methods. A single administration of the extract resulted in general sedation, suppressing all the individual and social activities with the exception of some submissive elements. The locomotive and the overall activity of drugged males was drastically reduced and immobility occurred frequently. After four applications, tolerance to the sedative effects had developed and behavioral drug effects were recognizable. Drugged males showed an increase in nonsocial activities as well as in submissive behavior and flight, whereas social investigation was less frequent. Sexual and aggressive behavior was not significantly affected by the drug and immobility no longer occurred. In spite of behavioral changes after a single or repeated drug treatment, drugged males became dominant in about half the experiments. The nest-building behavior of males was disturbed in the same way after one or four drug applications. Drugged males generally refrained from carrying and working up the nesting material. The acute behavioral effects of hashish extract are compared to those described in previous papers and the difference between acute and subchronic drug effects is discussed.
采用行为学方法研究了大麻提取物（20毫克δ9 - 四氢大麻酚/千克）对遇到对照伙伴的雄性小鼠行为的急性和亚慢性影响。单次给予提取物会导致全身镇静，抑制所有个体和社交活动，但某些顺从行为除外。用药雄性小鼠的运动能力和整体活动大幅降低，且频繁出现不动状态。四次给药后，对镇静作用产生了耐受性，药物的行为效应变得明显。用药雄性小鼠的非社交活动、顺从行为和逃避行为增加，而社交探究则不那么频繁。药物对性行为和攻击行为没有显著影响，不动状态也不再出现。尽管单次或重复药物治疗后出现了行为变化，但在大约一半的实验中，用药雄性小鼠占据主导地位。一次或四次药物给药后，雄性小鼠的筑巢行为受到同样的干扰。用药雄性小鼠通常避免搬运和处理筑巢材料。将大麻提取物的急性行为效应与先前论文中描述的效应进行了比较，并讨论了急性和亚慢性药物效应之间的差异。
