Arnow P M, Fink J N, Schlueter D P, Barboriak J J, Mallison G, Said S I, Martin S, Unger G F, Scanlon G T, Kurup V P
Am J Med. 1978 Feb;64(2):236-42. doi: 10.1016/0002-9343(78)90051-7.
Symptoms of hypersensitivity pneumonitis in three employees in an office building led to an investigation of their work environment. An open spray water air cooling system was implicated when inhalation challenge with the spray water caused acute illness in one of them. A questionnaire survey of the 4,023 co-workers identified 48 other suspect cases, and laboaratory studies confirmed hypersensitivity pneumonitis in three additional workers of this group. A significant change in pulmonary function, occurring only after exposure to the work environment, was the most useful laboratory finding and was found in five workers with no other pulmonary abnormalities, but not is asymptomatic workers or controls, since five of the six patients with hypersensitivy pneumonitis worked in offices cooled by the spray water system and since three had positive responses to inhalation challenge, use of the spray water system was discontinued. The affected workers improved after they were removed from the office complex.
一座写字楼里三名员工出现过敏性肺炎症状，促使对他们的工作环境展开调查。当其中一人吸入喷雾水引发急性疾病时，开放式喷雾水空气冷却系统成为怀疑对象。对4023名同事进行的问卷调查又发现了48例疑似病例，实验室研究证实该组另外三名员工患有过敏性肺炎。肺功能仅在接触工作环境后出现显著变化，这是最有用的实验室检查结果，在五名无其他肺部异常的员工中发现了此情况，但无症状员工或对照组中未发现。由于六名过敏性肺炎患者中有五人在由喷雾水系统制冷的办公室工作，且三人吸入激发试验呈阳性，因此停用了喷雾水系统。患病员工搬离办公区域后病情有所改善。
