Aoki K, Kato M, Ohtsuka H, Ishii K, Nakazono N, Sawada H
Br J Ophthalmol. 1982 Dec;66(12):776-80. doi: 10.1136/bjo.66.12.776.
The clinical and aetiological findings are presented on 343 patients with clinical adenoviral conjunctivitis treated between July 1979 and July 1980 at 3 eye clinics in Sapporo. The age of the patients ranged from 12 days to 79 years, and the monthly incidence of the disease from 9 to 83, with clustering in the summer season. The aetiological diagnosis was established in 196 (57%) of 343 patients: adenovirus 3 in 24 cases; adenovirus 4 in 33 cases, including one case serologically diagnosed; adenovirus 8 in 124 cases; and adenovirus 19 in 15 cases. The different serotypes caused different clinical pictures. Adenovirus 19 conjunctivitis was more severe, with keratitis and preauricular lymphadenopathy more frequent than that of adenovirus 3 conjunctivitis. Adenovirus 4 conjunctivitis was generally similar to adenovirus 3 conjunctivitis. The clinical difference between the 2 groups adenoviruses 3 and 4, and adenoviruses 8 and 9, was statistically significant. Although in Japan adenovirus 8 was the most prevalent, adenoviruses 4 and 19 should be considered as causative agents of adenoviral conjunctivitis.
本文介绍了1979年7月至1980年7月间在札幌市3家眼科诊所接受治疗的343例临床腺病毒性结膜炎患者的临床及病因学研究结果。患者年龄从12天至79岁不等，该病的月发病率为9至83例，发病集中在夏季。343例患者中有196例（57%）确诊病因：24例为腺病毒3型；33例为腺病毒4型，其中1例经血清学诊断；124例为腺病毒8型；15例为腺病毒19型。不同血清型引起不同的临床表现。腺病毒19型结膜炎病情更严重，与腺病毒3型结膜炎相比，角膜炎和耳前淋巴结病更为常见。腺病毒4型结膜炎一般与腺病毒3型结膜炎相似。腺病毒3型和4型以及腺病毒8型和9型两组之间的临床差异具有统计学意义。尽管在日本腺病毒8型最为常见，但腺病毒4型和19型也应被视为腺病毒性结膜炎的病原体。
