谢菲尔德生殖器溃疡的致病微生物菌群，特别提及单纯疱疹病毒和杜克雷嗜血杆菌。
Pathogenic microbial flora of genital ulcers in Sheffield with particular reference to herpes simplex virus and Haemophilus ducreyi.
作者信息
Kinghorn G R, Hafiz S, McEntegart M G
出版信息
Br J Vener Dis. 1982 Dec;58(6):377-80. doi: 10.1136/sti.58.6.377.
Abstract
The pathogenic microbial flora of genital ulcers in 161 (80 men and 81 women) unselected patients was studied prospectively. In only one case was Treponema pallidum responsible whereas herpes simplex virus was considered to be the cause of 130 (80.8%) genital ulcers. H ducreyi was isolated from 46 (28.6%) patients, most commonly as a secondary pathogen in herpetic lesions. Two or more pathogens were isolated from the ulcers in 67 (41.6%) patients, and in 21 (13%) patients no pathogens were isolated. Our results indicate an urgent need for antiviral treatment to reduce the local reservoir of genital herpes, challenge traditional concepts about the prevalence of H ducreyi in Britain, and call for a reappraisal of its role in the causation of genital ulcers.
摘要
对161例（80名男性和81名女性）未经挑选的生殖器溃疡患者的致病微生物菌群进行了前瞻性研究。仅1例由梅毒螺旋体引起，而单纯疱疹病毒被认为是130例（80.8%）生殖器溃疡的病因。从46例（28.6%）患者中分离出杜克雷嗜血杆菌，最常见的是作为疱疹性病变中的继发病原体。67例（41.6%）患者的溃疡中分离出两种或更多病原体，21例（13%）患者未分离出病原体。我们的结果表明，迫切需要进行抗病毒治疗以减少生殖器疱疹的局部病灶，挑战英国关于杜克雷嗜血杆菌流行率的传统观念，并呼吁重新评估其在生殖器溃疡病因中的作用。
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