Geppert M, Bachmann F F
Geburtshilfe Frauenheilkd. 1982 Oct;42(10):732-5. doi: 10.1055/s-2008-1037152.
Three cases of cystosarcoma phylloides of the breast are presented. The different microscopic presentations are discussed. The therapeutic and prognostic importance of the histologic differences are discussed. Even after excision of the tumour in what appears to be benign types, recurrence must be expected. The recurrent tumour often shows a higher degree of atypia. The same conclusion is reached in other cases in the literature. An excision of the tumor can only be considered to be sufficient treatment if the microscopic findings show a benign well incapsulated tumour with few cells and the excision has been done well in healthy tissue. This should only take place in young women. Since cystosarcoma phylloides can usually not be differentiated clinically or mammographically from fibro-adenomas not even by cytology all fibroadenomas of the breast must be removed and subjected to microscopic evaluation. A mistake in the microscopic evaluation may arise if not several areas of the tumours are examined. The treatment of choice in cystosarcoma phylloides is removal of the breast especially if there is a marked epithelial component to the carcinosarcoma, axillary lymphadenectomy and possibly postoperative radiation may be necessary.
本文报告了3例乳腺叶状囊肉瘤。讨论了不同的显微镜下表现。探讨了组织学差异在治疗和预后方面的重要性。即使在切除看似良性类型的肿瘤后,也必须预期会复发。复发性肿瘤通常表现出更高程度的异型性。文献中的其他病例也得出了相同的结论。只有当显微镜检查结果显示为良性、包膜完整、细胞较少且在健康组织中切除良好的肿瘤时,肿瘤切除才能被认为是充分的治疗。这只应在年轻女性中进行。由于叶状囊肉瘤通常在临床上、乳腺X线摄影甚至细胞学检查中都无法与纤维腺瘤区分开来,因此所有乳腺纤维腺瘤都必须切除并进行显微镜评估。如果不检查肿瘤的多个区域,可能会在显微镜评估中出现错误。叶状囊肉瘤的首选治疗方法是乳房切除,特别是如果癌肉瘤中有明显的上皮成分,可能需要进行腋窝淋巴结清扫和术后放疗。