注射测试前肾上腺素可逆转二甲基苯丙氨酸诱导的逆行性失忆。

Pre-test epinephrine injections reverse DDC-induced retrograde amnesia.

作者信息

Concannon J T, Carr M

出版信息

Physiol Behav. 1982 Sep;29(3):443-8. doi: 10.1016/0031-9384(82)90264-5.

Abstract

The effects of pre-test systemic administration of epinephrine on DDC-induced retrograde amnesia (RA) for discriminated Pavlovian fear-conditioning were examined in rats. Epinephrine reversed RA with the optimal dosage being 0.05 mg/kg. Apparently, the effect was specifically reversal of amnesia since (a) performance was restored to control levels, but no higher, and (b) sensitization and activity-related artifacts were minimized. These results are consistent with those showing reversal of RA by pre-test administration of hormones or catecholamine agonists. That is, they suggest that amnesia is due to a retrieval deficit rather than to failure of memory storage. Results are discussed in terms of epinephrine-induced modulation of storage and retrieval processes through central and peripheral mechanisms.

摘要

在大鼠中研究了预测试系统性给予肾上腺素对DDC诱导的辨别性巴甫洛夫恐惧条件反射逆行性遗忘（RA）的影响。肾上腺素可逆转RA，最佳剂量为0.05mg/kg。显然，这种作用是特异性的遗忘逆转，因为（a）行为表现恢复到对照水平，但不会更高，并且（b）敏化和与活动相关的假象被最小化。这些结果与那些通过预测试给予激素或儿茶酚胺激动剂逆转RA的结果一致。也就是说，它们表明遗忘是由于提取缺陷而非记忆存储失败。根据肾上腺素通过中枢和外周机制对存储和提取过程的调节来讨论结果。