Minneman K P, Wolfe B B, Molinoff P B
Brain Res. 1982 Dec 9;252(2):309-14. doi: 10.1016/0006-8993(82)90398-5.
The corpus striatum has a high density of beta-adrenergic receptors though it appears to contain low levels of beta-hydroxylated catecholamines. In an attempt to determine whether these receptors normally receive an endogenous input, the densities of beta 1 and beta 2-adrenergic receptors in rat caudate have been measured following adrenalectomy and after various pharmacological manipulations. Chronic administration of either pargyline, an inhibitor of monoamine oxidase activity, or desmethylimipramine, an inhibitor of norepinephrine uptake, resulted in a 20-25% decrease in the density of beta 1-adrenergic receptors while either adrenalectomy or the chronic administration of the non-selective beta-adrenergic receptor antagonist propranolol resulted in small but significant increases in the density of beta 1-receptors. These treatments did not lead to significant changes in the density of beta 2-receptors. It thus appears that the density of beta 1-receptors in the caudate is normally affected by changing levels of endogenous catecholamines.
纹状体中β-肾上腺素能受体密度很高，尽管其所含β-羟基化儿茶酚胺水平似乎较低。为了确定这些受体是否正常接受内源性输入，在大鼠尾状核中，分别于肾上腺切除术后以及经过各种药理学处理后，对β1和β2-肾上腺素能受体的密度进行了测量。长期给予单胺氧化酶活性抑制剂帕吉林或去甲肾上腺素摄取抑制剂去甲替林，会导致β1-肾上腺素能受体密度降低20% - 25%，而肾上腺切除术或长期给予非选择性β-肾上腺素能受体拮抗剂普萘洛尔，则会使β1-受体密度出现虽小但显著的增加。这些处理并未导致β2-受体密度发生显著变化。因此，尾状核中β1-受体的密度似乎通常会受到内源性儿茶酚胺水平变化的影响。
