Goyette M, Petropoulos C J, Shank P R, Fausto N
Science. 1983 Feb 4;219(4584):510-2. doi: 10.1126/science.6297003.
The number of transcripts of the cellular oncogene ras, which is homologous to the transforming gene of Harvey sarcoma virus, increases during liver regeneration in rats. The increase in these transcripts in liver polysomal polyadenylated RNA occurs at the time of activation of DNA synthesis during the regenerative process induced by partial hepatectomy or carbon tetrachloride injury. The number of ras transcripts returns to basal levels within 72 hours. These observations show that transcription of a cellular oncogene increases in a regulated way in a nonneoplastic growth process.
与哈维肉瘤病毒的转化基因同源的细胞癌基因ras的转录本数量在大鼠肝脏再生过程中增加。在部分肝切除或四氯化碳损伤诱导的再生过程中，DNA合成激活时，肝脏多聚核糖体多聚腺苷酸化RNA中的这些转录本数量增加。ras转录本数量在72小时内恢复到基础水平。这些观察结果表明，细胞癌基因的转录在非肿瘤性生长过程中以一种受调控的方式增加。
