Meijlink F C, Philipsen J N, Gruber M, Ab G
Nucleic Acids Res. 1983 Mar 11;11(5):1361-73. doi: 10.1093/nar/11.5.1361.
The degree of methylation of the chicken vitellogenin gene has been investigated. Upon induction by administration of estradiol to a rooster, methyl groups at specific sites near the 5'-end of the gene are eliminated. The process of demethylation is slower than the activation of the gene. Demethylation is therefore probably not a prerequisite to gene transcription. At least two other sites in the coding region of the gene are methylated in the liver of estrogenized roosters, but not in the liver of a laying hen, where the gene is naturally active.
已经对鸡卵黄生成素基因的甲基化程度进行了研究。给一只公鸡注射雌二醇进行诱导后，该基因5'-末端附近特定位点的甲基基团被去除。去甲基化过程比基因激活过程要慢。因此，去甲基化可能不是基因转录的先决条件。在经雌激素处理的公鸡肝脏中，该基因编码区至少还有另外两个位点发生甲基化，但在该基因自然活跃的产蛋母鸡肝脏中则没有。
