影响5'CCGG序列的DNA甲基转移酶
DNA methyltransferases affecting the sequence 5'CCGG.
作者信息
Jentsch S, Günthert U, Trautner T A
出版信息
Nucleic Acids Res. 1981 Jun 25;9(12):2753-9. doi: 10.1093/nar/9.12.2753.
Abstract
B. subtilis phage SPbeta and Moraxella sp. code for DNA methyltransferases which methylate both cytosines of the sequence 5'CCGG. Experiments using a B. subtilis strain whose DNA is sensitive to HpaII and resistant to MspI degradation, indicated that methylation of the outer C of this sequence provides protection against the restriction enzyme MspI.
摘要
枯草芽孢杆菌噬菌体SPbeta和莫拉克斯氏菌属编码DNA甲基转移酶，该酶可使序列5'CCGG的两个胞嘧啶甲基化。使用DNA对HpaII敏感且对MspI降解具有抗性的枯草芽孢杆菌菌株进行的实验表明，该序列外部胞嘧啶的甲基化可提供对限制酶MspI的保护。
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