du Vivier A
Arch Dermatol. 1976 Sep;112(9):1245-8. doi: 10.1001/archderm.112.9.1245.
Acute tolerance to the vasoconstrictive effect of topically applied glucocorticoids in humans has recently been described. Similar acute tolerance to the antiproliferative properties of topically applied steroids in proliferating and normal hairless mouse epidermis is now shown to occur. Thus, at first, topically applied steroids cause profound inhibition of DNA synthesis and mitosis in the epidermis, but with continued treatment, DNA synthesis and mitosis recover and the tissue becomes insensitive to further stimulation. This suggests that there is an optimum approach to therapy with topically applied steroids that might reduce the incidence of side effects and improve therapeutic efficacy.
最近已报道了人类对局部应用糖皮质激素的血管收缩作用产生急性耐受性。现在发现，在增殖性和正常无毛小鼠表皮中，对局部应用类固醇的抗增殖特性也存在类似的急性耐受性。因此，起初局部应用类固醇会导致表皮中DNA合成和有丝分裂受到显著抑制，但随着持续治疗，DNA合成和有丝分裂会恢复，并且组织对进一步刺激变得不敏感。这表明存在一种局部应用类固醇的最佳治疗方法，可能会降低副作用的发生率并提高治疗效果。
