超氧化物歧化酶可抑制的四氧嘧啶自由基对细胞色素c的还原作用。对四氧嘧啶细胞毒性的影响。
Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity.
作者信息
Winterbourn C C
出版信息
Biochem J. 1982 Dec 1;207(3):609-12. doi: 10.1042/bj2070609.
Abstract
Cytochrome c was reduced when superoxide was generated from xanthine oxidase in the presence of alloxan, and by the reaction of alloxan and with reduced glutathione. In each case, most of the reduction was inhibited by superoxide dismutase, but considerably more enzyme was required than with superoxide alone. This indicates that the superoxide dismutase-inhibitible cytochrome c reduction was mainly due to a direct reaction with the alloxan radical, and implies that other reactions that are inhibited by superoxide dismutase could be due to either alloxan radicals or superoxide.
摘要
当在四氧嘧啶存在的情况下，由黄嘌呤氧化酶产生超氧化物时，以及通过四氧嘧啶与还原型谷胱甘肽的反应，细胞色素c会被还原。在每种情况下，大部分还原反应都受到超氧化物歧化酶的抑制，但所需的酶量比单独使用超氧化物时要多得多。这表明超氧化物歧化酶可抑制的细胞色素c还原主要是由于与四氧嘧啶自由基的直接反应，这意味着其他受超氧化物歧化酶抑制的反应可能是由于四氧嘧啶自由基或超氧化物引起的。
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