Yeager H, Russo D A, Yañez M, Gerardi D, Nolan R P, Kagan E, Langer A M
Environ Res. 1983 Feb;30(1):224-32. doi: 10.1016/0013-9351(83)90182-2.
Studies were performed to compare the cytotoxicity for human alveolar macrophages of a naturally occurring short-fiber chrysotile asbestos (RG 144) to that of a standard reference mixed-fiber (long and short) chrysotile asbestos (UICC chrysotile A. Rhodesian). Parallel studies were also performed with quartz (Min-U-Sil 15), a known macrophage toxin. On a mass basis, and after 24 hr incubation, RG 144 was more cytotoxic than the UICC standard reference fiber and less toxic than quartz (silica). The cytotoxic potential of RG 144 chrysotile was further enhanced after size reduction by milling. These findings may have important biologic implications with respect to the use of short-fiber asbestos in industry.
开展了多项研究，以比较天然存在的短纤维温石棉（RG 144）与人肺泡巨噬细胞的细胞毒性，以及与标准参考混合纤维（长纤维和短纤维）温石棉（UICC温石棉A. 罗德西亚型）的细胞毒性。还对已知的巨噬细胞毒素石英（Min-U-Sil 15）进行了平行研究。以质量计，在孵育24小时后，RG 144的细胞毒性比UICC标准参考纤维更强，且毒性比石英（二氧化硅）更低。通过研磨减小尺寸后，RG 144温石棉的细胞毒性潜力进一步增强。这些发现可能对工业中使用短纤维石棉具有重要的生物学意义。
