Bonina L, Iannello D, Merendino R, Arena A, Mastroeni P
Infect Immun. 1983 Feb;39(2):575-9. doi: 10.1128/iai.39.2.575-579.1983.
By their position at sites of initial infection and their wide distribution in major organs of the body, macrophages may be decisive in determining the susceptibility or resistance of the host to virus infection. Macrophage restriction of virus replication has been shown to be closely related to virus strains or virus types and to the age of the infected host. We report the effects of the development of a solid tumor in rats on intrinsic in vitro macrophage activity against herpes simplex virus type 1. The results obtained with the infectious center assays and the analysis of single-cycle growth curves of herpes simplex virus type 1 in macrophages obtained from normal and tumor-bearing rats showed a depression of antiviral activity of macrophages from tumor-bearing rats. The possibility of immunomodulation by bacterial adjuvants on tumor-bearing rats and the effects on the antiviral activity of peritoneal macrophages were furthermore demonstrated.
巨噬细胞因其在初始感染部位的位置以及在身体主要器官中的广泛分布，可能在决定宿主对病毒感染的易感性或抵抗力方面起决定性作用。巨噬细胞对病毒复制的限制已被证明与病毒株或病毒类型以及受感染宿主的年龄密切相关。我们报告了大鼠实体瘤的发展对其体内巨噬细胞针对1型单纯疱疹病毒的固有体外活性的影响。通过感染中心试验以及对从正常大鼠和荷瘤大鼠获得的巨噬细胞中1型单纯疱疹病毒单周期生长曲线的分析所得到的结果表明，荷瘤大鼠巨噬细胞的抗病毒活性受到抑制。此外，还证明了细菌佐剂对荷瘤大鼠进行免疫调节的可能性及其对腹膜巨噬细胞抗病毒活性的影响。
