利用针对单纯疱疹病毒2型所特有的两种75,000分子量糖蛋白的单克隆抗体进行糖蛋白鉴定和基因定位。
Use of monoclonal antibodies against two 75,000-molecular-weight glycoproteins specified by herpes simplex virus type 2 in glycoprotein identification and gene mapping.
作者信息
Para M F, Zezulak K M, Conley A J, Weinberger M, Snitzer K, Spear P G
出版信息
J Virol. 1983 Mar;45(3):1223-7. doi: 10.1128/JVI.45.3.1223-1227.1983.
Abstract
We produced two monoclonal antibodies that precipitate different glycoproteins of similar apparent molecular weight (70,000 to 80,000) from extracts of cells infected with herpes simplex virus type 2. Evidence is presented that one of these glycoproteins is the previously characterized glycoprotein gE, whereas the other maps to a region of the herpes simplex virus type 2 genome collinear with the region in herpes simplex virus type 1 DNA that encodes gC.
摘要
我们制备了两种单克隆抗体，它们能从感染2型单纯疱疹病毒的细胞提取物中沉淀出表观分子量相似（70,000至80,000）的不同糖蛋白。有证据表明，其中一种糖蛋白是先前已鉴定的糖蛋白gE，而另一种则定位于2型单纯疱疹病毒基因组中与1型单纯疱疹病毒DNA中编码gC的区域共线的区域。
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