在选择用于结合单纯疱疹病毒粒子的单克隆抗体中，与抗糖蛋白D特异性相关的强效中和活性。
Potent neutralizing activity associated with anti-glycoprotein D specificity among monoclonal antibodies selected for binding to herpes simplex virions.
作者信息
Para M F, Parish M L, Noble A G, Spear P G
出版信息
J Virol. 1985 Aug;55(2):483-8. doi: 10.1128/JVI.55.2.483-488.1985.
Abstract
Thirty-three monoclonal antibodies were selected for ability to bind to purified virions of herpes simplex virus and were shown by immunoprecipitation to react with one or another of the envelope glycoproteins. Only six of these antibodies exhibited potent neutralizing activity, and all six were specific for glycoprotein D. Two other anti-glycoprotein D antibodies and 25 antibodies specific for four other viral glycoproteins had much less potent, if any, neutralizing activity.
摘要
挑选出33种单克隆抗体，检测其与单纯疱疹病毒纯化病毒粒子的结合能力，通过免疫沉淀法显示它们与一种或另一种包膜糖蛋白发生反应。其中只有6种抗体表现出强效中和活性，且这6种均对糖蛋白D具有特异性。另外两种抗糖蛋白D抗体以及针对其他四种病毒糖蛋白的25种抗体，即便有中和活性，其效力也低得多。
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