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非洲爪蟾核糖体DNA转录间隔区的多种异质性

Multiple heterogeneities in the transcribed spacers of ribosomal DNA from Xenopus laevis.

作者信息

Stewart M A, Hall L M, Maden B E

出版信息

Nucleic Acids Res. 1983 Feb 11;11(3):629-46. doi: 10.1093/nar/11.3.629.

DOI:10.1093/nar/11.3.629
PMID:6300760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC325742/
Abstract

Ribosomal DNA (rDNA) from Xenopus laevis contains several heterogeneities in all three transcribed spacers, as revealed by analysis of cloned and uncloned amplified rDNA from oocytes and cloned chromosomal rDNA from erythrocytes. Heterogeneities include single base changes and length variants of one to several nucleotides. Sites of variation are widely but non-uniformly distributed, some occurring only a short distance outside the boundaries of the rRNA coding regions. No two transcription units that we have yet examined are identical throughout their transcribed spacer regions.

摘要

非洲爪蟾的核糖体DNA（rDNA）在所有三个转录间隔区均存在多种异质性，这是通过对卵母细胞中克隆和未克隆的扩增rDNA以及红细胞中克隆的染色体rDNA进行分析得出的。异质性包括单碱基变化以及一到几个核苷酸的长度变异。变异位点分布广泛但并不均匀，有些仅出现在rRNA编码区边界外很短的距离处。我们迄今所研究的转录单位在其转录间隔区都不完全相同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e8/325742/084f7cdecda3/nar00348-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e8/325742/d5e906e3bbcc/nar00348-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e8/325742/09555214b972/nar00348-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e8/325742/084f7cdecda3/nar00348-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e8/325742/d5e906e3bbcc/nar00348-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e8/325742/09555214b972/nar00348-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e8/325742/084f7cdecda3/nar00348-0090-a.jpg

相似文献

1
Multiple heterogeneities in the transcribed spacers of ribosomal DNA from Xenopus laevis.非洲爪蟾核糖体DNA转录间隔区的多种异质性
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2
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5
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The origin of the rRNA precursor from Xenopus borealis, analysed in vivo and in vitro.对来自北方爪蟾的rRNA前体的起源进行体内和体外分析。
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Patterns of major divergence between the internal transcribed spacers of ribosomal DNA in Xenopus borealis and Xenopus laevis, and of minimal divergence within ribosomal coding regions.北方爪蟾和非洲爪蟾核糖体DNA内部转录间隔区的主要差异模式，以及核糖体编码区内的最小差异。
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Nucleotide sequence of the 18S-26S rRNA intergene region of the sea urchin.海胆18S - 26S rRNA基因间隔区的核苷酸序列。
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引用本文的文献

1
Patterns of major divergence between the internal transcribed spacers of ribosomal DNA in Xenopus borealis and Xenopus laevis, and of minimal divergence within ribosomal coding regions.北方爪蟾和非洲爪蟾核糖体DNA内部转录间隔区的主要差异模式，以及核糖体编码区内的最小差异。
EMBO J. 1983;2(3):443-8. doi: 10.1002/j.1460-2075.1983.tb01442.x.
2
Recognition of the Xenopus ribosomal core promoter by the transcription factor xUBF involves multiple HMG box domains and leads to an xUBF interdomain interaction.转录因子xUBF对非洲爪蟾核糖体核心启动子的识别涉及多个HMG盒结构域，并导致xUBF结构域间相互作用。
EMBO J. 1993 Feb;12(2):513-25. doi: 10.1002/j.1460-2075.1993.tb05683.x.
3

本文引用的文献

1
The nucleotide sequence of the intergenic region between the 5.8S and 26S rRNA genes of the yeast ribosomal RNA operon. Possible implications for the interaction between 5.8S and 26S rRNA and the processing of the primary transcript.酵母核糖体RNA操纵子中5.8S和26S rRNA基因之间基因间区域的核苷酸序列。对5.8S和26S rRNA之间相互作用以及初级转录本加工的可能影响。
Nucleic Acids Res. 1981 Oct 10;9(19):4847-62. doi: 10.1093/nar/9.19.4847.
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Secondary structure comparisons between small subunit ribosomal RNA molecules from six different species.来自六个不同物种的小亚基核糖体RNA分子之间的二级结构比较。
Nucleic Acids Res. 1981 Aug 11;9(15):3621-40. doi: 10.1093/nar/9.15.3621.
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The external transcribed spacer and preceding region of Xenopus borealis rDNA: comparison with the corresponding region of Xenopus laevis rDNA.
非洲爪蟾核糖体DNA的外部转录间隔区及前导区域：与非洲爪蟾核糖体DNA相应区域的比较。
Nucleic Acids Res. 1983 Dec 10;11(23):8183-96. doi: 10.1093/nar/11.23.8183.
4
Human 18 S ribosomal RNA sequence inferred from DNA sequence. Variations in 18 S sequences and secondary modification patterns between vertebrates.从DNA序列推断出的人类18 S核糖体RNA序列。脊椎动物之间18 S序列和二级修饰模式的变化。
Biochem J. 1985 Dec 15;232(3):725-33. doi: 10.1042/bj2320725.
5
Characterization of mouse 45S ribosomal RNA subspecies suggests that the first processing cleavage occurs 600 +/- 100 nucleotides from the 5' end and the second 500 +/- 100 nucleotides from the 3' end of a 13.9 kb precursor.小鼠45S核糖体RNA亚类的特征表明，第一次加工切割发生在距13.9 kb前体5'端600±100个核苷酸处，第二次切割发生在距3'端500±100个核苷酸处。
Nucleic Acids Res. 1985 Jul 11;13(13):4905-19. doi: 10.1093/nar/13.13.4905.
6
Clones of human ribosomal DNA containing the complete 18 S-rRNA and 28 S-rRNA genes. Characterization, a detailed map of the human ribosomal transcription unit and diversity among clones.包含完整18 S - rRNA和28 S - rRNA基因的人类核糖体DNA克隆。特征分析、人类核糖体转录单位的详细图谱以及克隆间的多样性。
Biochem J. 1987 Sep 1;246(2):519-27. doi: 10.1042/bj2460519.
7
Endonuclease G: a (dG)n X (dC)n-specific DNase from higher eukaryotes.核酸内切酶G：一种来自高等真核生物的（dG）n X（dC）n特异性脱氧核糖核酸酶。
EMBO J. 1987 Feb;6(2):401-7. doi: 10.1002/j.1460-2075.1987.tb04769.x.
8
28 S ribosomal RNA in vertebrates. Locations of large-scale features revealed by electron microscopy in relation to other features of the sequences.脊椎动物中的28S核糖体RNA。电子显微镜揭示的大规模特征的位置与序列的其他特征的关系。
Biochem J. 1989 Feb 15;258(1):49-56. doi: 10.1042/bj2580049.
9
Nucleotide sequences of the 5.8S rRNA gene and internal transcribed spacer regions in carrot and broad bean ribosomal DNA.胡萝卜和蚕豆核糖体DNA中5.8S rRNA基因及内转录间隔区的核苷酸序列。
J Mol Evol. 1989 Oct;29(4):294-301. doi: 10.1007/BF02103617.
10
A sequence dimorphism in a conserved domain of human 28S rRNA. Uneven distribution of variant genes among individuals. Differential expression in HeLa cells.人类28S rRNA保守结构域中的序列二态性。变异基因在个体间分布不均。在HeLa细胞中的差异表达。
Nucleic Acids Res. 1991 Mar 11;19(5):1015-9. doi: 10.1093/nar/19.5.1015.
Nucleotide sequence of Xenopus laevis 18S ribosomal RNA inferred from gene sequence.
从基因序列推断出的非洲爪蟾18S核糖体RNA的核苷酸序列。
Nature. 1981 May 21;291(5812):205-8. doi: 10.1038/291205a0.
4
More ribosomal spacer sequences from Xenopus laevis.来自非洲爪蟾的更多核糖体间隔序列。
Nucleic Acids Res. 1980 Feb 11;8(3):467-85. doi: 10.1093/nar/8.3.467.
5
18S coding sequences in amplified ribosomal DNA from Xenopus laevis oocytes are highly homogeneous, unmethylated, and lack major open reading frames.非洲爪蟾卵母细胞扩增核糖体DNA中的18S编码序列高度同源、未甲基化且缺乏主要开放阅读框。
EMBO J. 1982;1(5):597-601. doi: 10.1002/j.1460-2075.1982.tb01214.x.
6
Nucleotide sequence of the region between the 18S rRNA sequence and the 28S rRNA sequence of rat ribosomal DNA.大鼠核糖体DNA的18S rRNA序列与28S rRNA序列之间区域的核苷酸序列。
Nucleic Acids Res. 1982 Jun 25;10(12):3667-80. doi: 10.1093/nar/10.12.3667.
7
Nucleotide sequence of an external transcribed spacer in Xenopus laevis rDNA: sequences flanking the 5' and 3' ends of 18S rRNA are non-complementary.非洲爪蟾核糖体DNA中外转录间隔区的核苷酸序列：18S核糖体RNA 5'和3'末端侧翼的序列不互补。
Nucleic Acids Res. 1982 Apr 10;10(7):2387-98. doi: 10.1093/nar/10.7.2387.
8
Nucleotide sequence through the 18S-28S intergene region of a vertebrate ribosomal transcription unit.脊椎动物核糖体转录单位18S - 28S基因间隔区的核苷酸序列。
Nucleic Acids Res. 1980 Dec 20;8(24):5993-6005. doi: 10.1093/nar/8.24.5993.
9
Some characteristics of processing sites in ribosomal precursor RNA of yeast.酵母核糖体前体RNA加工位点的一些特征。
Nucleic Acids Res. 1980 Jul 11;8(13):2907-20. doi: 10.1093/nar/8.13.2907.
10
Fine structure of ribosomal RNA. III. Location of evolutionarily conserved regions within ribosomal DNA.核糖体RNA的精细结构。III. 核糖体DNA中进化保守区域的定位
J Mol Biol. 1980 Jun 25;140(2):321-39. doi: 10.1016/0022-2836(80)90109-6.