Jungkunz G, Engel R R, King U G, Kuss H J
Psychiatry Res. 1983 Jan;8(1):13-8. doi: 10.1016/0165-1781(83)90133-6.
This study investigates the role of endogenous opioids in the regulation of pain in humans. Two groups of healthy volunteers were subjected to different stress situations (cold pressor and arithmetic). In a double-blind design the changes in pain tolerance after stress were measured after an injection of either 0.8 mg naloxone or placebo. The cold pressor test raised the pain threshold in the placebo-treated group, but not in the naloxone-treated group. Mental arithmetic had no effect on pain perception. One can conclude therefore that physical stress may change pain perception depending upon the secretion of endogenous opioids.
本研究调查内源性阿片类物质在人类疼痛调节中的作用。两组健康志愿者分别经历不同的应激情况（冷加压和算术）。在双盲设计中，注射0.8毫克纳洛酮或安慰剂后，测量应激后疼痛耐受性的变化。冷加压试验提高了安慰剂治疗组的疼痛阈值，但纳洛酮治疗组未提高。心算对疼痛感知没有影响。因此可以得出结论，身体应激可能根据内源性阿片类物质的分泌改变疼痛感知。
