从愈合伤口中分离胶原刺激因子。
Isolation of collagen stimulating factors from healing wounds.
作者信息
O'Hare R P, Fallon A, Bradley J F, Burns J, McGee J O
出版信息
J Clin Pathol. 1983 Jun;36(6):707-11. doi: 10.1136/jcp.36.6.707.
Abstract
Five factors (collagen stimulating factors) have been isolated from healing murine skin wounds which stimulate prolyl hydroxylase activity and collagen synthesis in mouse fibroblasts in vitro. These factors stimulate general protein synthesis to a much smaller extent. Collagen stimulating factors are detectable in wounds three days after healing begins and disappear after six days when healing is complete. These data indicate that these factors may modulate collagen production during wound healing.
摘要
已从正在愈合的小鼠皮肤伤口中分离出五种因子（胶原蛋白刺激因子），它们在体外可刺激小鼠成纤维细胞中的脯氨酰羟化酶活性和胶原蛋白合成。这些因子对一般蛋白质合成的刺激程度要小得多。在愈合开始三天后的伤口中可检测到胶原蛋白刺激因子，愈合完成六天后这些因子消失。这些数据表明，这些因子可能在伤口愈合过程中调节胶原蛋白的产生。
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本文引用的文献
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Collagen proline hydroxylase activity and 35S sulphate uptake in human liver biopsies.人肝活检组织中胶原蛋白脯氨酸羟化酶活性及35S硫酸盐摄取情况
Gut. 1974 Apr;15(4):260-7. doi: 10.1136/gut.15.4.260.
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Stimulation of the collagen biosynthetic pathway by factors isolated from experimentally-injured liver.从实验性损伤肝脏中分离出的因子对胶原蛋白生物合成途径的刺激作用。
Nat New Biol. 1973 May 23;243(125):121-3.
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