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抗坏血酸对胶原蛋白生物合成的调节：综述

Regulation of collagen biosynthesis by ascorbic acid: a review.

作者信息

Pinnell S R

出版信息

Yale J Biol Med. 1985 Nov-Dec;58(6):553-9.

PMID:3008449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2589959/
Abstract

L-ascorbic acid is an essential cofactor for lysyl hydroxylase and prolyl hydroxylase, enzymes essential for collagen biosynthesis. In addition, L-ascorbic acid preferentially stimulates collagen synthesis in a manner which appears unrelated to the effect of L-ascorbic acid on hydroxylation reactions. This reaction is stereospecific and unrelated to intracellular degradation of collagen. The effect apparently occurs at a transcriptional or translational level, since L-ascorbic acid preferentially stimulates collagen-specific mRNA. In addition, it stimulates lysyl hydroxylase activity but inhibits prolyl hydroxylase activity in human skin fibroblasts in culture.

摘要

L-抗坏血酸是赖氨酰羟化酶和脯氨酰羟化酶的必需辅助因子，这两种酶对胶原蛋白的生物合成至关重要。此外，L-抗坏血酸以一种似乎与L-抗坏血酸对羟化反应的影响无关的方式优先刺激胶原蛋白合成。该反应具有立体特异性，且与胶原蛋白的细胞内降解无关。这种作用显然发生在转录或翻译水平，因为L-抗坏血酸优先刺激胶原蛋白特异性mRNA。此外，它在培养的人皮肤成纤维细胞中刺激赖氨酰羟化酶活性，但抑制脯氨酰羟化酶活性。

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本文引用的文献

1
Procollagen I synthesis in human skin fibroblasts: effect on culture conditions on biosynthesis.人皮肤成纤维细胞中I型前胶原的合成：培养条件对生物合成的影响。
J Invest Dermatol. 1980 Nov;75(5):425-30. doi: 10.1111/1523-1747.ep12524080.
2
Regulation of collagen synthesis by ascorbic acid. Ascorbic acid increases type I procollagen mRNA.抗坏血酸对胶原蛋白合成的调节作用。抗坏血酸可增加I型前胶原mRNA的含量。
Biochem Biophys Res Commun. 1982 May 31;106(2):632-7. doi: 10.1016/0006-291x(82)91157-3.
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Collagen degradation in human lung fibroblasts: extent of degradation, role of lysosomal proteases, and evaluation of an alternate hypothesis.人肺成纤维细胞中的胶原蛋白降解：降解程度、溶酶体蛋白酶的作用以及对另一种假说的评估
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Collagen synthesis in cultured human skin fibroblasts: effect of ascorbic acid and its analogs.培养的人皮肤成纤维细胞中的胶原蛋白合成：抗坏血酸及其类似物的作用。
J Invest Dermatol. 1983 Aug;81(2):158-62. doi: 10.1111/1523-1747.ep12543573.
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Regulation of prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts by ascorbic acid.抗坏血酸对培养的人皮肤成纤维细胞中脯氨酰羟化酶和赖氨酰羟化酶活性的调节
Biochem Biophys Res Commun. 1981 Aug 14;101(3):868-75. doi: 10.1016/0006-291x(81)91830-1.
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Regulation of collagen synthesis by ascorbic acid.抗坏血酸对胶原蛋白合成的调节作用。
Proc Natl Acad Sci U S A. 1981 May;78(5):2879-82. doi: 10.1073/pnas.78.5.2879.
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The role of ascorbic acid in the biosynthesis of collagen. I. Ascorbic acid requirement by embryonic chick tibia in tissue culture.抗坏血酸在胶原蛋白生物合成中的作用。I. 组织培养中胚胎鸡胫骨对抗坏血酸的需求
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