在慢性粒细胞白血病中，c-sis从22号染色体易位至9号染色体。
c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia.
作者信息
Groffen J, Heisterkamp N, Stephenson J R, van Kessel A G, de Klein A, Grosveld G, Bootsma D
出版信息
J Exp Med. 1983 Jul 1;158(1):9-15. doi: 10.1084/jem.158.1.9.
Abstract
By analysis of a series of somatic cell hybrids derived by fusion of either mouse or Chinese hamster cells with leukocytes from different chronic myelocytic leukemia (CML) patients or from normal donors, we have localized the human oncogene, c-sis, on the q11 to qter segment of chromosome 22 and demonstrated its translocation from chromosome 22 to chromosome 9 (q34) in CML.
摘要
通过分析一系列由小鼠或中国仓鼠细胞与来自不同慢性粒细胞白血病（CML）患者或正常供体的白细胞融合产生的体细胞杂种，我们已将人类癌基因c-sis定位在22号染色体的q11至qter区段，并证明了它在慢性粒细胞白血病中从22号染色体易位至9号染色体（q34）。
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