在K562白血病细胞中，扩增的Cλ和c-abl基因位于同一条标记染色体上。
Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells.
作者信息
Selden J R, Emanuel B S, Wang E, Cannizzaro L, Palumbo A, Erikson J, Nowell P C, Rovera G, Croce C M
出版信息
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7289-92. doi: 10.1073/pnas.80.23.7289.
The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C lambda genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C lambda DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.
源自一名费城染色体阳性慢性粒细胞白血病患者的人白血病细胞系K562，含有扩增的c-abl癌基因和未重排的Cλ基因。利用原位杂交技术，我们已确定K562细胞中扩增的c-abl和CλDNA序列均位于同一条异常近端着丝粒标记染色体上，该染色体可能代表一条改变的费城染色体。
Zotero 插件