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果蝇线粒体DNA一段序列的核苷酸序列,该序列包含细胞色素c氧化酶亚基II和III以及ATP酶亚基6的基因。

Nucleotide sequence of a segment of Drosophila mitochondrial DNA that contains the genes for cytochrome c oxidase subunits II and III and ATPase subunit 6.

作者信息

Clary D O, Wolstenholme D R

出版信息

Nucleic Acids Res. 1983 Jun 25;11(12):4211-27. doi: 10.1093/nar/11.12.4211.

Abstract

The nucleotide sequence of a segment of the mtDNA molecule of Drosophila yakuba has been determined, within which have been identified the genes for tRNAleuUUR, cytochrome c oxidase subunit II (COII), tRNAlys, tRNAasp, URFA6L, ATPase subunit 6 (ATPase6), cytochrome c oxidase subunit III (COIII) and tRNAgly. The genes are arranged in the order given and all are transcribed from the same strand of the molecule in a direction opposite to that in which replication proceeds around the molecule. The tRNAlys gene is unusual among mitochondrial tRNAlys genes in that it contains a CTT anticodon. The triplet AGA is used to specify an amino acid in all of the COII, COIII, ATPase6, and URFA6L genes. However, the AGA codons found in these four polypeptide genes correspond in position to codons which specify nine different amino acids, but never arginine, in the equivalent polypeptide gene which have been sequenced from mtDNAs of mouse, yeast and Zea mays.

摘要

已确定了雅库布果蝇线粒体DNA(mtDNA)分子一段的核苷酸序列,其中已鉴定出tRNAleuUUR、细胞色素c氧化酶亚基II(COII)、tRNAlys、tRNAasp、URFA6L、ATP酶亚基6(ATPase6)、细胞色素c氧化酶亚基III(COIII)和tRNAgly的基因。这些基因按给定顺序排列,且全部从分子的同一条链转录,转录方向与分子复制方向相反。tRNAlys基因在线粒体tRNAlys基因中不同寻常,因为它含有CTT反密码子。三联体AGA在所有COII、COIII、ATPase6和URFA6L基因中用于指定一种氨基酸。然而,在这四个多肽基因中发现的AGA密码子在位置上与从小鼠、酵母和玉米的mtDNA测序得到的等效多肽基因中指定九种不同氨基酸(但从不指定精氨酸)的密码子相对应。

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Sequence and gene organization of mouse mitochondrial DNA.小鼠线粒体DNA的序列与基因组织
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